Erectile Dysfunction Is a Common Problem of Men with Diabetes
Erectile dysfunction is a common problem for more than half of men with diabetes. A recent study from the Brady Urological Institute at Johns Hopkins suggests that an over-supply of a simple blood sugar could be a major cause of erectile dysfunction in diabetic men.
Describing the mechanism of erection, the research team has determined that high glucose in diabetes mellitus is an interrupting factor of this process.
Erection begins when a sexual stimulus activates the enzyme neuronal nitric oxide synthase (nNOS) that causes short-term release of nitric oxide (NO) at the nerve endings in the penis.
This initial release of NO causes short-term and rapid increases in penile blood flow and short-term relaxation of the penile smooth muscle, initiating an erection. The resulting expansion of penile blood vessels and smooth-muscle relaxation allows more blood to flow into the penis. This increased blood flow (shear stress) activates the eNOS in penile blood vessels causing sustained NO release, continued relaxation and full erection.
O-GlcNAc, a blood sugar present in hyperglycemic (high blood sugar) circumstances, hinders this normal chain of events by inhibiting the activation of eNOS, and consequently reducing the release of NO and preventing the smooth muscle in the penis from relaxing. Without this relaxation, there is no shear stress to stoke the production of more NO and therefore, no normal, sustained erection.
This is not the same type of erectile dysfunction seen in non-diabetics, and it is less effectively treated with conventional drugs like Viagra. The mechanism described above stresses the critical importance of vascular function in the erectile response. It may suggest new ways of treating erectile dysfunction by targeting specifically this mechanism in penile erection.
Valerian D is a freelance writer specialized in health issues affecting men http://www.mens-health-events.info/diabetes.php
Diabetes and Insulin - Diabetes is a condition in which the body either does not manufacture sufficient amounts of insulin or does not properly use insulin. Insulin is a hormone made by the pancreas that is necessary for the transport of ...
Getting Personal About Your Diabetes - Diabetes is a nasty disease, so much so that we don't even look at its bright side. And, diabetes is controllable. Tight control will prevent much of what hurts people most. It's as simple and as complex as that. Co ...
Diabetes : Plain Talk About The Basics - Diabetes is basically a disease that interferes with the ability of our bodies to use food for energy and growth. One thing that happens when we digest food is that some of it is converted into glucose (sugar) that ...
Zyprexa and Diabetes Compensation - Zyprexa and Diabetes Eli Lilly & Co. has agreed to pay nearly $700 million to settle a nationwide class action for Zyprexa patients that developed Diabetes. Alternate Names for Zyprexa: olan ...
White Sun on Health - Diabetes - Diabetes currently affects 7% of the United States population, or 20.8 million Americans, and more than half are women. Diabetes is the 6th leading cause of death today, and a large percentage of diabetics don't eve ...
For a Complete list of Articles with summaries Click Here